穴位贴敷联合蜡疗治疗肝胃不和证功能性消化不良：随机对照试验

杨晓忱; 柳兰萍; 李依润; 冯玲; 杨涛; 高寅秋

doi:10.13703/j.0255-2930.20240621-k0005

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穴位贴敷联合蜡疗治疗肝胃不和证功能性消化不良：随机对照试验

临床研究 | 更新时间：2025-06-13

- 穴位贴敷联合蜡疗治疗肝胃不和证功能性消化不良：随机对照试验
- Functional dyspepsia of liver-stomach disharmony treated with acupoint application of Chinese herbal medicine and wax therapy: a randomized controlled trial
- 中国针灸 2025年45卷第6期页码：728-734
- 作者机构：
  
  中国中医科学院广安门医院疼痛科，北京 100053
  中国中医科学院广安门医院针灸科，北京 100053
  中国中医科学院广安门医院干部保健科，北京 100053
- 作者简介：
  
  ✉高寅秋，主任医师。E-mail：gaoyinqiu@gamyy.cn
- 基金信息：
  
  中国中医科学院科技创新工程项目(CI2021A03006)
- DOI：10.13703/j.0255-2930.20240621-k0005
  中图分类号：
- 收稿：2024-06-21，
  
  网络首发：2024-12-18，
  
  纸质出版：2025-06-12
- 稿件说明：
移动端阅览
杨晓忱, 柳兰萍, 李依润, 等. 穴位贴敷联合蜡疗治疗肝胃不和证功能性消化不良：随机对照试验[J]. 中国针灸, 2025,45(6):728-734.

YANG Xiaochen, LIU Lanping, LI Yirun, et al. Functional dyspepsia of liver-stomach disharmony treated with acupoint application of Chinese herbal medicine and wax therapy: a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2025, 45(6): 728-734.
杨晓忱, 柳兰萍, 李依润, 等. 穴位贴敷联合蜡疗治疗肝胃不和证功能性消化不良：随机对照试验[J]. 中国针灸, 2025,45(6):728-734. DOI： 10.13703/j.0255-2930.20240621-k0005.

YANG Xiaochen, LIU Lanping, LI Yirun, et al. Functional dyspepsia of liver-stomach disharmony treated with acupoint application of Chinese herbal medicine and wax therapy: a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2025, 45(6): 728-734. DOI： 10.13703/j.0255-2930.20240621-k0005.

摘要

目的：

观察基于田从豁教授“调理气机”理论的中药穴位贴敷联合蜡疗治疗肝胃不和证功能性消化不良（FD）的临床疗效。

方法：

将120例肝胃不和证FD患者随机分为联合组（30例，脱落1例）、单纯贴敷组（30例，脱落1例）、单纯蜡疗组（30例，脱落1例）和基础治疗组（30例，脱落2例）。基础治疗组予口服奥美拉唑镁肠溶片，每次20 mg，每日1次。在基础治疗组基础上，单纯贴敷组于中脘、神阙行中药穴位贴敷，每次4 h；单纯蜡疗组于腹部中脘至神阙区域予蜡疗，每次20 min；联合组予中药穴位贴敷联合蜡疗，均每隔1~2天1次，每周 3 次。4组均治疗4周。分别于治疗前后观察患者主要症状积分、简明生活质量量表（SF-36）评分及肝胃不和证积分，并评定临床疗效。

结果：

治疗后，4组患者各项主要症状积分和肝胃不和证积分低于治疗前（

0.01）；联合组、单纯贴敷组患者SF-36各维度评分高于治疗前（

0.01，

0.05），单纯蜡疗组患者SF-36生理机能、躯体疼痛、总体健康、精力、社会功能、精神健康评分高于治疗前（

0.01，

0.05），基础治疗组患者SF-36生理职能、躯体疼痛、总体健康、精神健康评分高于治疗前（

0.05，

0.01）。治疗后，联合组患者餐后饱胀不适积分低于基础治疗组及单纯蜡疗组（

0.01），早饱、上腹痛、上腹烧灼感积分及肝胃不和证积分低于其余3组（

0.01，

0.05）；SF-36生理机能、生理职能、躯体疼痛评分高于基础治疗组（

0.01，

0.05），生理机能、躯体疼痛评分高于单纯贴敷组（

0.01，

0.05），生理机能、精力评分高于单纯蜡疗组（

0.05）。治疗后，单纯贴敷组患者各项主要症状积分、肝胃不和证积分及单纯蜡疗组患者肝胃不和证积分低于基础治疗组（

0.01，

0.05）。联合组、单纯贴敷组、单纯蜡疗组、基础治疗组总有效率分别为93.3%（28/30）、73.3%（22/30）、66.7%（20/30）和50.0%（15/30），联合组总有效率高于其余3组（

0.01），单纯贴敷组、单纯蜡疗组总有效率高于基础治疗组（

0.01）。

结论：

基于田从豁教授“调理气机”理论的中药穴位贴敷联合蜡疗可有效治疗FD，减轻主要症状，改善生活质量。

Abstract

Objective

To investigate the clinical effect on functional dyspepsia differentiated as liver-stomach disharmony treated with acupoint application of Chinese herbal medicine and wax therapy on the basis of Professor

TIAN Conghuo

's theory

"regulating

movement".

Methods

A total of 120 patients with functional dyspepsia of liver-stomach disharmony were randomly assigned to a combined therapy group (30 cases

1 case dropped out)

an acupoint application group (30 cases

1 case dropped out)

a wax therapy group (30 cases

1 case dropped out) and a basic therapy group (30 cases

2 cases dropped out). In the basic therapy group

omeprazole magnesium enteric-coated tablets were administered orally

20 mg each time

once daily. Besides the treatment as the basic therapy group

the Chinese herbal acupoint application was used at Zhongwan (CV12) and Shenque (CV8) in the acupoint application group

and remained for 4 h in each intervention; and in the wax therapy group

wax therapy was delivered at the sites of Zhongwan (CV12) and Shenque (CV8) of the abdominal region and remained for 20 min in each intervention; and in the combined therapy group

the acupoint application was combined with wax therapy

administered once every other day or every two days

3 times weekly. The duration of treatment was 4 weeks in the four groups. Before and after treatment

the score of main symptoms

the score of 36-item short-form health survey (SF-36) and the score of liver-stomach disharmony pattern were observed; and the clinical effect was evaluated in the four groups.

Results

After treatment

regarding main symptoms and liver-stomach disharmony pattern

the score of every item was lower than that before treatment in the 4 groups (

0.01). The score for each dimension in SF-36 was higher than that before treatment in the combined therapy group and the acupoint application group (

0.01

0.05). In the wax therapy group

the scores for physiological activities

bodily pain

general health

vitality

social activities and mental health in SF-36 were higher than those before treatment (

0.01

0.05). In the basic therapy group

the scores for physiological performance

bodily pain

general health and mental health in SF-36 were higher than those before treatment (

0.05

0.01). After treatment

in the combined therapy group

the score for gastric distension and discomforts was lower than those of the basic therapy group and the wax therapy group (

0.01)

and the scores for gastric fullness in the morning

pain in the upper abdominal region and burning sensation in the upper abdominal region

as well as the score for liver-stomach disharmony pattern were lower than those in the rest 3 groups (

0.01

0.05). In the combined therapy group

the scores

for physiological activities

physiological performance

and bodily pain were higher than those of the basic therapy group (

0.01

0.05)

the scores for physiological activities and bodily pain were higher when compared with those in the acupoint application group (

0.01

0.05) and the scores for physiological activities and vitality were higher when compared with those in the wax therapy group (

0.05). After treatment

the score for each item of main symptoms

the score for liver-stomach disharmony pattern in the acupoint application group

and the score for liver-stomach disharmony pattern in the wax therapy group were all lower in comparison with those in the basic therapy group (

0.01

0.05). The total effective rates was 93.3% (28/30)

73.3% (22/30)

66.7% (20/30) and 50.0% (15/30) in the combined therapy group

the acupoint application group

the wax therapy group and the basic therapy group

respectively; and the total effective rate in the combined therapy group was superior to the other 3 groups (

0.01); the total effective rates in the acupoint application group and the wax therapy group were higher than that in the basic therapy group (

0.01).

Conclusion

The combination of acupoint application with Chinese herbal medicine and wax therapy

based on Professor

TIAN Conghuo

's theory of "regulating

movement"

can effectively treat functional dyspepsia

alleviate main symptoms and improve the quality of life in the patients.

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