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南京中医药大学附属医院/江苏省中医院针灸康复科,南京 210029
✉陈璐,副主任中医师。E-mail:870315899@qq.com
收稿:2024-08-26,
网络首发:2024-11-01,
纸质出版:2025-02-12
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胡林雁, 孙建华, 裴丽霞, 等. 基于真实世界的急性期针灸治疗特发性面神经麻痹:队列研究[J]. 中国针灸, 2025,45(2):133-138.
HU Linyan, SUN Jianhua, PEI Lixia, et al. Effect of acupuncture-moxibustion on idiopathic facial palsy at acute phase in the real world: a cohort study[J]. Chinese Acupuncture & Moxibustion, 2025, 45(2): 133-138.
胡林雁, 孙建华, 裴丽霞, 等. 基于真实世界的急性期针灸治疗特发性面神经麻痹:队列研究[J]. 中国针灸, 2025,45(2):133-138. DOI: 10.13703/j.0255-2930.20240826-k0001.
HU Linyan, SUN Jianhua, PEI Lixia, et al. Effect of acupuncture-moxibustion on idiopathic facial palsy at acute phase in the real world: a cohort study[J]. Chinese Acupuncture & Moxibustion, 2025, 45(2): 133-138. DOI: 10.13703/j.0255-2930.20240826-k0001.
目的:
2
比较急性期和恢复期介入针灸对特发性面神经麻痹(IFP)的影响。
方法:
2
根据是否在急性期内接受针灸干预将198例IFP患者分为早期针灸组(118例)和非早期针灸组(80例),经倾向性评分匹配(PSM),最终早期针灸组与非早期针灸组各纳入70例。在西医常规治疗基础上,两组均接受针灸治疗,早期针灸组于急性期(病程≤7 d)介入针灸,非早期针灸组于恢复期(病程>7 d)介入针灸。急性期予温针灸治疗,穴取患侧翳风、下关、合谷、足三里;恢复期予电针治疗,穴取患侧攒竹、丝竹空、阳白等,予疏密波,频率2 Hz/100 Hz。均每次30 min,隔日1次,每周3次,共治疗4周。比较两组患者治疗前、治疗1周和治疗4周后House-Brackmann(H-B)面神经功能分级、Sunnybrook面神经功能评分和面部残疾指数(FDI)评分。并于治疗1、4周后评定两组临床疗效和安全性。
结果:
2
治疗1、4周后,两组患者H-B面神经功能分级均较治疗前改善(
P
<
0.05);治疗4周后,早期针灸组H-B面神经功能分级优于非早期针灸组(
P
<
0.05)。治疗1、4周后,两组患者Sunnybrook面神经功能评分、躯体功能评定(FDIP)评分较治疗前升高(
P
<
0.05);治疗4周后,早期针灸组Sunnybrook面神经功能评分、FDIP评分升高幅度大于非早期针灸组(
P
<
0.05)。治疗4周后,两组社会生活功能评定(FDIS)评分较治疗前降低(
P
<
0.05)。治疗4周后,早期针灸组总有效率(97.1%,68/70)高于非早期针灸组(87.1%,61/70,
P
<
0.05)。两组不良事件发生率比较差异无统计学意义(
P
>
0.05)。
结论:
2
在急性期介入针灸较恢复期介入针灸更有利于IFP患者受损面神经功能康复。
Objective
2
To compare the effect of acupuncture-moxibustion on idiopathic facial palsy (IFP) at acute phase and recovery phase.
Methods
2
According to whether received acupuncture-moxibustion at acute phase or not
198 IFP patients were divided into an early-phase intervention group (118 cases) and a non-early-phase intervention group (80 cases). With the propensity score matching employed
70 cases were included in each group. On the basis of the conventional treatment of western medicine
acupuncture-moxibustion was supplemented in the two groups. In the early-phase intervention group
acupuncture-moxibustion was delivered at the acute phase (duration of illness≤7 days); in the non-early-phase intervention group
acupuncture-moxibustion was operated at the recovery phase (duration of illness>7 days). At the acute phase
warm needling was performed at Yifeng (TE17)
Xiaguan (ST7)
Hegu (LI4) and Zusanli (ST36) on the affected side; and at the recovery phase
electroacupuncture was delivered at Cuanzhu (BL2)
Sizhukong (TE23) and Yangbai (GB14)
etc. on the affected side
with the disperse-dense wave and 2 Hz/100 Hz of frequency. The intervention was operated for 30 min each time
once every two days
three treatments weekly and for 4 weeks. Before treatment
1 week and 4 weeks of treatment
the House-Brackmann (H-B) facial nerve function grade
the score of Sunnybrook facial nerve function
and the score of facial disability index (FDI) were compared between the two groups. The clinical effect in 1 and 4 weeks of treatment and safety were evaluated.
Results
2
In 1 and 4 weeks of treatment
the H-B grade was improved when compared with that before treatment in each group (
P
<
0.05)
and in 4 weeks of treatment
H-B grade in the early-phase intervention group was superior to that of the non-early-phase intervention group (
P
<
0.05). In 1 and 4 weeks of treatment
Sunnybrook scores and the scores of physical function of FDI were elevated in comparison with those before treatment in the two groups (
P
<
0.05); and in 4 weeks of treatment
the elevation of these two indexes in the early-phase intervention group was greater than that of the non-early-phase intervention group (
P
<
0.05). In 4 weeks of treatment
the scores of social function in FDI were reduced when compared with those before treatment in the two groups (
P
<
0.05). In 4 weeks of treatment
the total effective rate (97.1%
68/70) in the early-phase intervention group was higher than that (87.1%
61/70) of the non-early-phase intervention group (
P
<
0.05). There was no significant difference in the incidence of adverse events between the two groups (
P
>
0.05).
Conclusion
2
Acupuncture-moxibustion therapy starting at the acute phase is more beneficial to the functional recovery of the impaired facial nerve than at the recovery phase in the IFP patients.
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