穴位埋线对帕金森病伴便秘患者肠道菌群及粪便短链脂肪酸的影响

张晓梅; 蒋捷; 李文英; 陈菊萍; 黄寅; 任伟; 宋亚芳; 孙建华

doi:10.13703/j.0255-2930.20241118-k0003

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穴位埋线对帕金森病伴便秘患者肠道菌群及粪便短链脂肪酸的影响

临床研究 | 更新时间：2025-11-20

- 穴位埋线对帕金森病伴便秘患者肠道菌群及粪便短链脂肪酸的影响
- Effects of acupoint catgut embedding on gut microbiota and fecal short-chain fatty acids in Parkinson's disease patients with constipation
- 中国针灸 2025年45卷第11期页码：1533-1540
- 作者机构：
  
  南京中医药大学附属医院针灸康复科，江苏南京　210029
  南京中医药大学常熟附属医院，江苏常熟　215500
  常熟市第五人民医院
  南通大学附属常熟医院
  南京中医药大学针灸推拿学院·养生康复学院
- 作者简介：
  
  ✉孙建华，主任中医师。E-mail：fsyy00657@njucm.edu.cn
- 基金信息：
  
  国家自然科学基金项目(82274630);江苏省中医药管理局项目(QN202101);常熟市科学技术局项目(CS202244;CS202227)
- DOI：10.13703/j.0255-2930.20241118-k0003
  中图分类号：
- 收稿：2024-11-18，
  
  网络首发：2025-02-06，
  
  纸质出版：2025-11-12
- 稿件说明：
移动端阅览
张晓梅, 蒋捷, 李文英, 等. 穴位埋线对帕金森病伴便秘患者肠道菌群及粪便短链脂肪酸的影响[J]. 中国针灸, 2025,45(11):1533-1540.

ZHANG Xiaomei, JIANG Jie, LI Wenying, et al. Effects of acupoint catgut embedding on gut microbiota and fecal short-chain fatty acids in Parkinson's disease patients with constipation[J]. Chinese Acupuncture & Moxibustion, 2025, 45(11): 1533-1540.
张晓梅, 蒋捷, 李文英, 等. 穴位埋线对帕金森病伴便秘患者肠道菌群及粪便短链脂肪酸的影响[J]. 中国针灸, 2025,45(11):1533-1540. DOI： 10.13703/j.0255-2930.20241118-k0003.

ZHANG Xiaomei, JIANG Jie, LI Wenying, et al. Effects of acupoint catgut embedding on gut microbiota and fecal short-chain fatty acids in Parkinson's disease patients with constipation[J]. Chinese Acupuncture & Moxibustion, 2025, 45(11): 1533-1540. DOI： 10.13703/j.0255-2930.20241118-k0003.

摘要

目的：

观察穴位埋线对帕金森病（PD）伴便秘患者肠道菌群及粪便短链脂肪酸（SCFAs）含量的影响。

方法：

将80例PD伴便秘患者随机分成观察组和对照组，每组40例。同期招募40例健康受试者作为健康组。对照组在PD常规西医治疗基础上服用聚乙二醇4000散，每日1次，治疗8周；观察组在对照组治疗基础上予穴位埋线治疗，以双侧天枢、足三里、上巨虚为主穴，每2周1次，治疗8周；健康组不予任何干预。于基线期末和治疗期末观察两组患者周自主排便次数（SBMs）、便秘患者生活质量（PAC-QOL）评分。观察组、对照组于治疗期末进行粪便样本采集，健康组于基线期末进行粪便样本采集，运用16S rRNA法检测肠道菌群结构和多样性，采用高效液相色谱分析粪便SCFAs含量。

结果：

治疗后，观察组患者SBMs较治疗前增多（

0.01），PAC-QOL躯体不适、心理社会不适、担心和焦虑评分及总分均较治疗前降低（

0.01）；对照组患者PAC-QOL总分较治疗前降低（

0.01）。治疗后，观察组患者SBMs多于对照组（

0.01），PAC-QOL躯体不适、心理社会不适、担心和焦虑评分及总分低于对照组（

0.01），PAC-QOL满意度评分高于对照组（

0.01）。与健康组比较，对照组患者Chao1指数和Ace指数降低（

0.01）。与健康组比较，对照组患者普雷沃氏菌和罗氏菌相对丰度升高（

0.05），肠杆菌、扭链瘤胃球菌等6种菌群的相对丰度降低（

0.05）。与对照组比较，观察组患者戴阿利斯特杆菌、副拟杆菌和扭链瘤胃球菌相对丰度升高（

0.05），普雷沃氏菌、瘤胃反刍真杆菌等4种菌群的相对丰度降低（

0.05）。与健康组比较，对照组患者粪便SCFAs含量升高（

0.05）；与对照组比较，观察组患者粪便SCFAs含量降低（

0.05）。与健康组比较，对照组患者粪便乙酸、丙酸、正丁酸含量升高（

0.05）；与对照组比较，观察组患者粪便乙酸、丙酸、正丁酸含量降低（

0.05）。

结论：

穴位埋线可增加帕金森病伴便秘患者自主排便次数、改善患者生活质量，可能与调节肠道菌群组成结构和SCFAs有关。

Abstract

Objective

To observe the effects of acupoint catgut embedding (ACE) on gut microbiota and fecal short-chain fatty acids (SCFAs) levels in patients with Parkinson's disease (PD) with constipation.

Methods

A total of 80 PD patients with constipation were randomly divided into an observation group and a control group

40 cases in each group. Additionally

40 healthy individuals were recruited as a healthy control group. The control group received conventional Western medical treatment for PD combined with polyethylene glycol (PEG)

once daily for eight weeks. The observation group received additional ACE treatment at bilateral Tianshu (ST25)

Zusanli (ST36)

and Shangjuxu (ST37)

once every two weeks for eight weeks. The healthy control group received no intervention. The spontaneous bowel movements (SBMs) per week and patient assessment of constipation quality of life (PAC-QOL) scores were assessed at baseline and after treatment in the two groups. Fecal samples were collected at the end of treatment for the observation and the control groups and at baseline for the healthy control group. Gut microbiota composition and diversity were analyzed using 16S rRNA method

and SCFA levels were measured using high-performance liquid chromatography (HPLC).

Results

Compared before treatment

the observation group showed a significant increase in SBMs (

0.01)

and PAC-QOL scores including physical discomfort

psychosocial discomfort

worry and concern

and total score were significantly reduced (

0.01) after treatment; the control group also showed a reduction in PAC-QOL total score after treatment (

0.01). After treatment

the observation group had significantly more SBMs (

0.01)

and lower PAC-QOL physical discomfort

psychosocial discomfort

worry and concern scores

and total score (

0.01)

and higher PAC-QOL satisfaction score (

0.01) tha

n the control group. Compared with the healthy control group

the control group showed decreased Chao1 and Ace indices (

0.01). Compared with the healthy control group

the relative abundance of

Prevotella

and

Roseburia

was increased (

0.05)

while that of

Enterobacter

and

Ruminococcus torques

(six species in total) was decreased (

0.05) in the control group. Compared with the control group

the observation group had increased relative abundance of

Dialister

Parabacteroides

and

Ruminococcus torques

(

0.05)

and decreased relative abundance of

Prevotella

and

Eubacterium ruminantium

(

0.05). Compared with the healthy control group

the control group had increased fecal SCFA levels (

0.05); compared with the control group

the observation group had reduced fecal SCFA levels (

0.05). Compared with the healthy control group

acetic acid

propionic acid

and butyric acid levels were elevated in the control group (

0.05); compared with the control group

acetic acid

propionic acid

and butyric acid levels were decreased in the observation group (

0.05).

Conclusion

ACE could increase spontaneous bowel movements and improve the quality of life in PD patients with constipation

which may be related to the regulation of gut microbiota composition and SCFA levels.

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